Publications

selected publications (original papers) since 2010
 
Berger E, Rath E, Detian Y, Waldschmitt N, Khaloian S, Allgäuer M, Staszewski O, Lobner EM, Schöttl T, Giesbertz P, Coleman OI, Prinz M, Weber A, Gerhard M, Klingenspor M, Janssen KP, Heikenwalder M, Haller D
Mitochondrial function controls intestinal epithelial stemness and proliferation
Nature Communications 2016 7:13171
Impact factor (journal citation report 2015):   11.329

Finan, B., Clemmensen, C., Zhu, Z., Stemmer, K., Gauthier, K., Müler, L., de Angelis, M., Moreth, K., Neff, F., Perez-Tilve, D., Fischer, K., Lutter, D., Sanches-Garrido, M.A., Liu, P., Healy, M. E., Malehmir, M., Weber, A., Heikenwälder, M., Jastroch, M., Kleinert, M., Brandt, S., Flamant, F., Schramm, K., Biebermann, H., Döring, Y., Weber, C., Habegger, K.M., Keuper, M., Gelfanov, V., Liu, F., Köhrle, J., Rozman, J., Fuchs, H., Gailus-Durner V, Hrabe de Angelis, M., Hofmann, S.M., Yang, B., Tschöp, MH., Di Marchi, R., Müller, T.D.
Selective targeting of T3 via glucagon transport offers precision metabolic therapy without thyrotoxicity
Cell 2016 167(3):843-857
Impact factor (journal citation report 2015): 28.71

Sacré A, Lanthier N, Dano H, Aydin S, Leggenhager D, Weber A, Dekairelle AF, De Cuyper A, Gala JL, Humblet Y, Sempoux C, van den Eyde M
Regorafenib induced severe toxic hepatitis: characterization and discussion
Liver International 2016 doi: 10.1111/liv.13217. [Epub ahead of print]
Impact factor (journal citation report 2015): 4.71

Koppe C, Verheugd P, Gautheron J, Reisinger F, Kreggenwinkel K, Roderburg C, Quagliata L, Terracciano L, Gassler N, Tolba RH, Boege Y, Weber A, Karin M, Luedde M, Neumann UP, Weiskirchen R, Tacke F, Vucur M, Trautwein C, Lüscher B, Preisinger C, Heikenwalder M, Luedde T
IKKα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator RIPK1
Hepatology 2016 64(4):1217-31
Impact factor (journal citation report 2014):   11.055

Scherr AL, Gdynia G, Salou M, Radhakrishnan P, Duglova K, Heller A, Keim S, Kautz N, Jassowicz A, Elssner C, HE YW, Jaeger D, Heikenwalder M, Schneider M, Weber A, Roth W, Schulze-Bergkamen H, Köhler B
Bcl-xL is an oncogenic driver in colorectal cancer
Cell Death Dis 2016 7(8):e2342
Impact factor (journal citation report 2014):   5.014

Ma C, Kesarwala AH, Eggert T, Medina-Echeverz J, Kleiner DE, Jin P, Stroncek DF, Terabe M, Kapoor V, ElGindi M, Han M, Thornton AM, Zhang H, Egger M, Luo J, Felsher DW, McVicar DW, Weber A, Heikenwalder M, Greten TF
NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis
Nature 2016 531(7593):253-7
Impact factor (journal citation report 2014):   41.456

Matter MS, Marquardt JU, Andersen JB, Quintavalle C, Korokhov N, Stauffer JK, Kaji K, Decaens T, Quagliata L, Elloumi F, Hoang T, Molinolo A, Conner EA, Weber A, Heikenwalder M, Factor VM, Thorgeirsson SS
Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype
Hepatology 2016 Epub ahead of print
Impact factor (journal citation report 2014):   11.055

Tschuor C, Kachaylo E, Perparim L, Raptis DA, Linecker M, Tian Y, Herrmann U, Grabliauskaite K, Weber A, Columbano A, Graf R, Humar B*, Clavien PA*
Car-driven regeneration protects liver from failure following tissue loss and bears therapeutic potential
Journal of Hepatology 2016 [Epub ahead of print]
Impact factor (journal citation report 2014):   11.336

Meier R, Lutz C, Cosín-Roger J, Fagagnini S, Bollmann G, Hünerwadel A, Mamie C, Lang S, Tchouboukov A, Weber FE, Weber A, Rogler G, Hausmann M
Decreased Fibrogenesis After Treatment with Pirfenidone in a Newly Developed Mouse Model of Intestinal Fibrosis
Inflamm Bowel Dis 2016 22(3):569-82
Impact factor (journal citation report 2014):   4.464

Mertz KD*, Mager LF*, Wasmer MH, Thiesler T, Koelzer VH, Ruzzante G, Joller S, Murdoch JR, Brümmendorf T, Gentisch V, Lugli A, Cathomas G, Moch H, Weber A, Zlobec I, Junt T, Krebs P
The 1 IL-33/ST2 pathway contributes to intestinal tumorigenesis in humans and mice
Oncoimmunology 2016 26;5(1):e1062966. eCollection
Impact factor (journal citation report 2014):   6.266

Weber A, Heikenwalder M
P(URI)fying novel drivers of NASH and HCC: A feed-forward loop of IL17A via white adipose tissue
Cancer Cell 2016 30(1):15-7
Impact factor (journal citation report 2014): 23.523

Koelzer VH, Glatz K, Weber A, Flatz L, Cathomas G, Zippelius A, Mertz KD
Wirkungen und Nebenwirkungen der Tumor-Immuntherapie
SWISS MEDICAL FORUM – SCHWEIZERISCHES MEDIZIN-FORUM 2016;16(51–52):1113–1115
Impact factor (journal citation report 2015):   2.086

Köhler UA, Böhm F, Rolfs F, Egger M, Hornemann T, Pasparakis M,  Weber A*#, Werner S*#
NF-κB/RelA and Nrf2 cooperate to maintain hepatocyte integrity and to prevent development of hepatocellular adenoma
Journal of Hepatology 2015 [Epub ahead of print]
Impact factor (journal citation report 2014): 11.336
*co-last authors, #co-corresponding authors
 
Tschuor C, Kachaylo E, Perparim L, Raptis DA, Linecker M, Tian Y, Herrmann U, Grabliauskaite K, Weber A, Columbano A, Graf R, Humar B, Clavien PA
Car-driven regeneration protects liver from failure following tissue loss and bears therapeutic potential
Journal of Hepatology 2015 (accepted)
Impact factor (journal citation report 2014): 11.336
 
Garnelo M, Tan A, Her Z, Yeong J, Lim CJ, Chen J, Lim KH, Weber A, Chow P, Chung A, Ooi LLPJ, Toh HC, Heikenwalder M, Ng IOL, Nardin A, Chen Q, Abastado JP, Chew V
Interaction between tumor-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma
Gut 2015 accepted
Impact factor (journal citation report 2014): 14.66
 
Weber A, O'Connor, Heikenwalder M
Next generation of pre-clinical liver cancer models
Clinical Cancer Research 2015
Impact factor (journal citation report 2014): 8.722
 
Mu X, Espanol-Suner R, Mederacke I, Manco R, Sempoux C, Affo S, Lemaigre FP, Adili A, Yuan D,  Weber A, Unger K, Heikenwalder M, Leclercq IA, Schwabe R
Hepatocellular carcinoma originates from hepatocytes and not from progenitor cells
Journal of Clinical Investigation 2015 125(10):3891-903
Impact factor (journal citation report 2014): 13.215
 
Friemel J, Frick L, Weber A
Intratumor heterogeneity in hepatocellular carcinoma
Aging 2015 7(6):350-1
Impact factor (journal citation report 2014): 6.432
 
Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL,Goossens N, Nakagawa S, Gunasekaran G, Schwartz ME, Kobayashi M, Kumada H, Berger M, Pappo O, Rajewski K, Hoshida Y, Karin M, Heikenwalder M,  Ben-Neriah Y, Pikarsky E
Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma
Nature Immunology 2015 [Epub ahead of print]
Impact factor (journal citation report 2014): 20.004
 
Chijioke O, Bawohl M, Springer E, Weber A
Hepatitis E Virus Detection in Liver Tissue from Patients with Suspected Drug-Induced Liver Injury
Frontiers in Medicine, Section Pathology 2015 2:20. doi: 10.3389
Impact factor (journal citation report 2013): not yet defined
 
Protzer U, Böhm B, Longerich T, Seebach J, Navid MH, Friemel J, Marques-Maggio E, Bawohl M, Heikenwalder M, Schirmacher P, Dutkowski P, Clavien PA, Schemmer P, Schnitzler P, Gotthardt D, Müllhaupt B, Weber A
Molecular detection of hepatitis E-virus (HEV) in liver biopsies after liver transplantation
Modern Pathology 2015 28(4):523-32
Impact factor (journal citation report 2013): 6.364

Friemel J, Rechsteiner M, Frick L, Böhm F, Struckmann K, Sigg  M, Moch H, Heikenwalder M, Weber A
Intratumor heterogeneity in hepatocellular carcinoma
Clinical Cancer Research 2015 21(8):1951-61
Impact factor (journal citation report 2013): 8.193
highlights of this issue: Implications for Tumor Classifications and Targeted Therapies Clinical Cancer Research 2015 21(8):1777
editorial: Nault & Villanueva Intratumor Molecular and Phenotypic Diversity in Hepatocellular Carcinoma Clinical Cancer Research 2015 21(8):1786-88

Wolf MJ, Adili A, Piotrowitz K, Abdullah Z, Boege Y, Stemmer K, Ringelhan M, Simonavicius N, Egger M, Wohlleber D, Lorentzen A, Einer C, Schulz S, Clavel T, Protzer U, Thiele C, Zischka H, Moch H, Tschöp M, Tumanov AV, Haller D, Unger U, Karin M, Kopf M, Knolle P*, Weber A*#, Heikenwalder M*#
*co-last authors, #co-corresponding authors
Metabolic activation of intrahepatic CD8+ and NKT-cells causes nonalcoholic steatohepatitis and hepatocellular carcinoma via cross-talk with hepatocytes
Cancer Cell 2014 26(4):549-64
Impact factor (journal citation report 2013): 23.893
cover page of Cancer Cell, Volume 26, Issue 4 October 13, 2014: Feedfoward loop for NKT and CD8+ cells in NASH and HCC

Malz M, Bovet M, Samarin J, Rabenhorst U, Sticht C, Bissinger M, Roessler S, Lorenzo Bermejo J, Renner M, Calvisi DF, Singer S, Ganzinger M, Weber A, Gretz N, Zörnig M, Schirmacher P, Breuhahn K
Overexpression of far upstream element (FUSE) binding protein (FBP)-interacting repressor (FIR) supports growth of hepatocellular carcinoma
Hepatology 2014 60(4):1241-50
Impact factor (journal citation report 2013): 11.19

Soldini D, Gaspert A, Montani M, Reineke T, Rogler G, Odze R, Weber A
Apoptotic enteropathy caused by antimetabolites and TNF-α antagonists
Journal of Clinical Pathology 2014 67(7):582-6
Impact factor (journal citation report 2013): 2.551

Rickenbacher A, Jang JH, Limani P, Ungethüm U, Lehmann K, Oberkofler CE, Weber A, Graf R, Bostjan H*, Clavien PA*
Fasting protects liver from ischemic injury through Sirt1-mediated downregulation of circulating Hmgb1 in mice
Journal of Hepatology 2014 61(2):301-8
Impact factor (journal citation report 2013): 10.401

Weber A, Marques-Maggio E
Apoptotic Colonopathy under Immunosuppression: Mycophenolate-Related Effects and Beyond
Pathobiology 2013 80(6):282-8
Impact factor (journal citation report 2013): 2.319

Vucur M, Reisinger F, Gautheron J, Janssen J, Roderburg C, Cardenas DV, Kreggenwinkel K, Koppe C, Hammerich L, Hakem R, Unger K, Weber A, Gassler N, Luedde M, Frey N, Neumann UP, Tacke F, Trautwein C, Heikenwalder M, Luedde T
RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling Caspase-8- and JNK-dependent compensatory cell proliferation
Cell Reports 2013 4(4):776-90
Impact factor (journal citation report 2013): 7.207

Spalinger MR, Lang S, Weber A, Frei P, Fried M, Rogler G, Scharl M
Loss of Protein Tyrosine Phosphatase Non-Receptor Type 22 Regulates Interferon-γ-Induced Signaling in Human Monocytes
Gastroenterology 2013 144(5):978-988
Impact factor (journal citation report 2013): 13.926

Lehmann K, Tschuor C, Rickenbacher A, Jang JH, Oberkofler CE, Tschopp O, Schulze S, Raptis DA, Weber A, Graf R, Humar B, Clavien PA
Liver Failure after Extended Hepatectomy in Mice is Mediated by a p21-Dependent Barrier to Liver Regeneration
Gastroenterology 2012 143(6):1609-1619
Impact factor (journal citation report 2012): 12.821

Wolf MJ, Hoos A, Bauer J, Boettcher S, Knust M, Weber A, Simonavicius N, Schneider C, Lang M, Stürzl M, Croner RS, Konrad A, Manz MG, Moch H, Aguzzi A, van Loo G, Pasparakis M, Prinz M, Borsig L, Heikenwalder M
Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway
Cancer Cell 2012 22(1):91-105
Impact factor (journal citation report 2012): 24.755

Chew V, Chen J, Lee D, Loh E, Lee J, Lim KH, Weber A, Slankamenac K, Poon RT, Yang H, Ooi LL, Toh HC, Heikenwalder M, Ng IO, Nardin A, Abastado JP
Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma
J Nat Cancer I 2012 104(23):1796-807
Impact factor (journal citation report 2012): 14.336

Jang JH, Rickenbacher A, Humar B, Weber A, Raptis DA, Lehmann K, Stieger B, Moritz W, Soll C, Georgiev P, Fischer D, Laczko E, Graf R, Clavien PA
Serotonin protects mouse liver from cholestatic injury by decreasing bile salt pool after bile duct ligation
Hepatology 2012 56(1):209-18
Impact factor (journal citation report 2012): 12.003

Raptis DA, Fischer MA, Graf R, Nanz D, Weber A, Moritz W, Tian Y, Oberkofler CE, Clavien PA
Resonance Imaging: The new reference standard in quantifying hepatic steatosis?
Gut 2012 61(1):117-27
Impact factor (journal citation report 2012): 10.732

Chew V, Chen J, Lee D, Loh E, Lee J, Lim KH, Weber A, Slankamenac K, Poon RT, Yang H, Ooi LL, Toh HC, Heikenwalder M, Ng IO, Nardin A, Abastado JP
Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma
Gut 2012 61(3):427-38
Impact factor (journal citation report 2012): 10.732

Brauckhoff A*, Malz M*, Tschaharganeh D, Malek N, Weber A, Riener MO, Soll S, Bissinger M,  Schmidt J, Longerich T, Ehemann V, Schirmacher P, Breuhahn K
Nuclear expression of the ubiquitin ligase seven in absentia homologue (SIAH)-1 induces proliferation and migration of liver cancer cells
J Hepatology 2011 55(5):1049-57
Impact factor (journal citation report 2012): 9.858

Scharl M, McCole DF, Weber A, Vavricka SR, Frei P, Kellermeier S, Pesch T, Fried M, Rogler G
Protein tyrosine phosphatase N2 regulates TNF{alpha}-induced signalling and cytokine secretion in human intestinal epithelial cells
Gut 2011 60(2):189-97
Impact factor (journal citation report 2012): 10.732

Ikenberg K, Springer E, Bräuninger W, Kerl K, Mihic D, Schmid S, Schmitt A, Yeginsoy S, Bode B, Weber A
Oropharyngeal lesions and cervical lymphadenopathy: syphilis is a differential diagnosis that is still relevant
J Clin Pathol 2010 63(8):731-6.
Impact factor (journal citation report 2012): 2.439

Bettermann K, Vucur M, Koppe C, Heymann F, Haybaeck J, Weber A, Weiskirchen R, Liedtke C, Gassler N, Müller M, Akira S, Tacke F, Heikenwalder M, Trautwein C, Luedde T
TAK1 suppresses a NEMO-dependent, but NF-B independent pathway to liver cancer
Cancer Cell 2010 17:481-496
Impact factor (journal citation report 2012): 24.755

Weber A*, Boger R*, Vick B, Urbanik T, Haybaeck J, Zoller S, Teufel A, Krammer PH, Opferman JT, Galle PR, Schuchmann M, Heikenwalder M, Schulze-Bergkamen H
Hepatocyte-specific deletion of the anti-apoptotic protein Mcl-1 triggers proliferation and hepatocarcinogenesis in mice
Hepatology 2010 51(4):1226-36
Impact factor (journal citation report 2012): 12.003
editorial: Jost  & Kaufmann  Cancer caused by too much apoptosis--an intriguing contradiction?
Hepatology 2010 51(4):1110-12

Weber A, Chung JH, Springer E, Heitzmann D, Warth R
The TFIIH subunit p89 (XPB) localizes to the centrosome during mitosis
Cellular Oncology 2010 32:121-130
Impact factor (journal citation report 2010): 3.175