Experimental and Molecular Pathology - Focus HPB and GI Pathology

Experimental and Molecular Pathology – Focus: Molecular Hepatobiliary and Gastrointestinal Pathology, Group Achim Weber

The University Hospital Zurich (USZ) has a major focus on diseases of the hepato-pancreato-biliary system and gastro-intestinal tract. The Swiss Hepato-Pancreato-Biliary (HPB) center and the ENTES (European neuroendocrine tumor society) center both are centers of excellence in Zurich for diseases of the liver, biliary tract and pancreas, and gastro-entero-pancreatic neuroendocrine (GEP-NET), respectively. A professorship was implemented in 2010 to cover the need of the University of Zurich (UZH) and the USZ in research and diagnostics in the field of liver, biliary tract, pancreas, and gastrointestinal pathology.

Weber, Achim (CV), group leader

Achim Weber obtained his M.D. degree from the University of Mainz, Germany. After a year of clinical internship in Hematology & Oncology at the University of Heidelberg, he started his training in Pathology. From 1998 to 2001 he was a visiting Fellow in the laboratory of Pathology at the National Cancer Institute, NIH, Bethesda, MD, USA. After this, he continued his training in clinical and molecular pathology, and completed his pathology residency at the Institute of Pathology, University of Mainz Germany in 2006. In addition to being board-certified as a pathologist, he received a board certification in molecular pathology in Germany as well as in Switzerland. His interest lies in clinical pathology and basic research in the field of hepatobiliary and gastrointestinal pathology.

Clinical pathology, diagnostic team and diagnostic profile

Egger Sigg, Michele, MD, pathology resident
Leibl, Sebastian, MD, staff pathologist
Lenggenhager, Daniela, MD, staff pathologist
Marques-Maggio, Ewerton, MD, PhD, staff pathologist
Vrugt, Bart, MD, PhD, staff pathologist

Diagnostic profile

The team covers the whole spectrum of diagnostic pathology in the field of liver, biliary tract, pancreas, and gastrointestinal pathology. A major focus is on diagnostic molecular pathology. Besides routine diagnostic cases, these fields comprise highly specialized works and activities, such as:
- Surgical pathology and molecular testing of cases within the Swiss Hepato-Pancreato-Biliary (HPB) center
- Surgical pathology of neuroendocrine tumors (NET Board)
- Molecular diagnostic of hereditary cancer syndromes including genetic testing (MEN1, MEN2, SDH, VHL >> Einsendung von Gewebeproben -> Endokrinologie)
- Second opinion and outside consultant cases in these fields

Surgical pathology service is performed in close interaction with clinical partners within the USZ and outside. The following clinical conferences are held on a regular basis:

1. Surgical-oncological (HPB) board (weekly)
2. Surgical-oncological (GIT) board (weekly)
3. Hepato-pathological conference (weekly)
4. NET board (biweekly)
5. Gastro-intestinal conferences (gastrointestinal clinics: USZ, Stadtspital Waid, Zürich, Spital Männedorf, GCZ - Gastro Club Zurich)

Research, team and research profile

Team

Research profile

The group has a focus on liver and intestinal carcinogenesis. These projects involve mouse models of diseases as well as analysis of human tissues. In addition to basic research projects, the group works on projects arising from routine diagnostic clinical and molecular pathology.

Research projects

Research collaborations

The group has several intramural and external collaborations including

Visceral Surgery (Pierre Alain Clavien, Rolf Graf), USZ, Zurich
Clinic for Gastroenterology and Hepatology (Beat Müllhaupt, Joachim Mertens, Gerhard Rogler, Michael Scharl), USZ, Zurich
Institute for Anesthesiology (Beatrice Beck-Schimmer), USZ, Zurich
Institute of Molecular Health Sciences (Sabine Werner), ETH Zurich
Institute of Virology (Matthias Heikenwälder, Ulrike Protzer), TU Munich, Germany
Institute of Pathology (Peter Schirmacher, Kai Breuhan, Thomas Longerich), University Heidelberg, Germany

Institute of Pathology (Erik Springer), University Mainz, Germany

Funding

Since 2010, external funding has been provided by the following organizations

  • Krebsliga Schweiz (KLS, Oncosuisse)
  • Swiss National Research Foundation (SNF)
  • Promedica Stiftung, Chur
  • Krebsliga Zürich (KLZH)
  • Julius Müller Stiftung zur Unterstützung der Krebsforschung, Zurich
  • Stiftung zur Krebsbekämpfung, Zürich
  • Theiler-Haag Stiftung, Zürich

Selected Publications since 2010

Master and Doctoral Thesis

The group offers Master and Doctoral thesis in the field of liver and gastrointestinal pathology with both, a basic research focus or a clinically oriented. Candidates interested may contact us.

Open Positions

Candidates interested may contact us.

Contact

Prof. Achim Weber
Institute of Surgical Pathology
UniversitätsSpital Zürich
Schmelzbergstrasse 12
8091 Zürich
Switzerland

Tel. +41 44 255 27 81
achim.weber@usz.ch